Are or might be pregnant; Mirena cannot be used as an emergency contraceptive
Have a serious pelvic infection called pelvic inflammatory disease (PID) or have had PID in the past unless you have had a normal pregnancy after the infection went away
Have an untreated pelvic or genital infection now
Have had a serious pelvic infection in the past 3 months after a pregnancy
Can get infections easily. For example, if you:
Have multiple sexual partners or your partner has multiple sexual partners
Have problems with your immune system
Use or abuse intravenous drugs
Have or suspect you might have cancer of the uterus or cervix
Have bleeding from the vagina that has not been explained
Have liver disease or a liver tumor
Have breast cancer or any other cancer that is sensitive to progestin (a female hormone), now or in the past
Have an intrauterine device in your uterus already
Have a condition of the uterus that changes the shape of the uterine cavity, such as large fibroid tumors
Are allergic to levonorgestrel, silicone, polyethylene, silica, barium sulfate or iron oxide
Have had a heart attack
Have had a stroke
Were born with heart disease or have problems with your heart valves
Have problems with blood clotting or take medicine to reduce clotting
Have AIDS, HIV, or any other sexually transmitted infection